Curriculum Vitae

Henrique Manuel dos Santos Faneca

Data da última atualização »Last update : 20/12/2014


Henrique Manuel dos Santos Faneca Publicou 27 artigos em revistas especializadas e 14 trabalhos em actas de eventos, possui 4 capítulos de livros publicados. Recebeu 1 prémio e/ou homenagem. Actua na área de Nanotecnologia Nas suas actividades profissionais interagiu com 128 colaboradores em co-autorias de trabalhos científicos.


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http://www.degois.pt/visualizador/curriculum.jsp?key=8461895212949390


Dados pessoais (Personal data)
Nome completo
Full name
Henrique Manuel dos Santos Faneca
Nome em citações bibliográficas
Quoting name
Faneca, Henrique
Domínio científico de atuação
Scientific domain
Engenharia e Tecnologia-Nanotecnologia.
Ciências Médicas-Ciências da Saúde.
Ciências Naturais-Ciências Biológicas.
Endereço profissional
Professional address
Universidade de Coimbra
Centro de Neurociências de Coimbra
Centro de Neurociências e Biologia Celular, Faculdade de Medicina, Polo I, Universidade de Coimbra
Coimbra
3004-517 Coimbra
Portugal
Telefone: (+351)239820190
Correio electrónico: henrique@cnc.uc.pt
Sexo
Gender
Masculino»Male




Graus Académicos (Academic Degrees)
2001-2005 Doutoramento
Phd
Bioquímica (4 anos » years) .
Universidade de Coimbra, Portugal.

1998-2001 Mestrado
Master degree
Mestrado em Biologia Celular (2 anos » years) .
Universidade de Coimbra, Portugal.

1991-1996 Licenciatura
Licentiate degree
Bioquímica (5 anos » years) .
Universidade de Coimbra, Portugal.





Línguas (Languages)
Compreende
Understandig
Inglês (Razoavelmente), Francês (Pouco), Espanhol (Pouco).
Fala
Speaking
Inglês (Razoavelmente), Francês (Pouco), Espanhol (Pouco).

Reading
Inglês (Bem), Francês (Pouco), Espanhol (Pouco).
Escreve
Writing
Inglês (Bem), Francês (Pouco), Espanhol (Pouco).




Prémios e títulos (Awards Prizes, and Honours)
1990 Prémio de melhor aluno, Escola Secundária de Vagos.




Produção científica, técnica e artística/cultural (Scientific, technical and artistical/cultural production)
Capítulos de livros publicados
Published book chapters
1. Faneca, H; AL, Cardoso; Trabulo, S.; Duarte, S.; Pedroso de L. M. 2013. Cationic liposome-based systems for nucleic acid delivery: from the formulation development to therapeutic applications..  In Drug delivery systems: advanced technologies potentially applicable in personalized treatments, 153 - 184. . Dordrecht: Springer Science+Business Media.
Faneca H, Cardoso AL, Trabulo S, Duarte S, Pedroso de Lima MC. Cationic liposome-based systems for nucleic acid delivery: from the formulation development to therapeutic applications. In: Drug delivery systems: advanced technologies potentially applicable in personalized treatments, Advances in Predictive, Preventive and Personalised Medicine, 2013, pp. 153-184 (Coelho J, ed), Springer Science+Business Media, Dordrecht.

2. Faneca, Henrique; Düzgünes, Nejat; Lima, Maria C. P. 2010. Fluorescence Methods for Evaluating Lipoplex-Mediated Gene Delivery.  In Liposomes, ed. Volkmar Weissig, 425 - 437. ISBN: 978-1-60761-446-3. Totowa, NJ: Humana Press.
3. Düzgünes, Nejat; Faneca, Henrique; Lima, Maria C. P. 2010. Methods to Monitor Liposome Fusion, Permeability, and Interaction with Cells.  In Liposomes, ed. Volkmar Weissig, 209 - 232. ISBN: 978-1-60761-446-3. Totowa, NJ: Humana Press.
4. Pedroso De L. M; Faneca, H.; Mano, M.; Penacho, N.; Düzgünes, N.; Simões, S.. 2003. Biophysical characterization of cationic liposome-DNA complexes and their interaction with cells.  In Methods in Enzymology, 298 - 312. ISBN: 978-0-08-049712-9. SAN DIEGO: ELSEVIER ACADEMIC PRESS INC.

Artigos em revistas com arbitragem científica
Papers in periodics with scientific refereeing
1. Passadouro, Marta; Pedroso de L. M; Faneca, Henrique. 2014. "MicroRNA modulation combined with sunitinib as a novel therapeutic strategy for pancreatic cancer", International Journal of Nanomedicine, 9: 3203 - 3217.
2. Farinha, Dina; Pedroso de L. M. C; Faneca, Henrique. 2014. "Specific and efficient gene delivery mediated by an asialofetuin-associated nanosystem", International Journal of Pharmaceutics 473, 1-2: 366 - 374.
3. M, Magalhães; Farinha, Dina; Pedroso de L. M; Faneca, H. 2014. "Increased gene delivery efficiency and specificity of a lipid-based nanosystem by incorporating a glycolipid", Int. J. Nanomedicine  9, 1: 4979 - 4989.
4. Gonçalves, Filipa A. M. M; Costa, Cátia S. M. F; Fabela, Inês G. P; Farinha, Dina; Faneca, Henrique; Simões, Pedro N; Serra, Arménio C; Bártolo, Paulo J; Coelho, Jorge F. J. 2014. "3D printing of new biobased unsaturated polyesters by microstereo-thermal-lithography", Biofabrication 6, 3: 035024 - 035024.
5. Cordeiro, Rosemeyre A; Farinha, Dina; Rocha, Nuno; Serra, Arménio C; Faneca, Henrique; Coelho, Jorge F. J. 2014. " Novel Cationic Triblock Copolymer of Poly[2-(dimethylamino)ethyl methacrylate]- block -poly(ß-amino ester)- block -poly[2-(dimethylamino)ethyl methacrylate]: A Promising Non-Viral Gene Delivery System ", Macromolecular Bioscience, 2014: n/a - n/a.
6. Duarte, Sónia; Faneca, Henrique; Lima, Maria C. P.. 2012. "Folate-associated lipoplexes mediate efficient gene delivery and potent antitumoral activity in vitro and in vivo", International Journal of Pharmaceutics 423, 2: 365 - 377.
7. Duarte, S.; Loubat, A.; Momier, D.; Topi, M.; Faneca, H; Pedroso de L. M; Carle, Georges; Pierrefite-Carle, V.. 2012. "Isolation of head and neck squamous carcinoma cancer stem-like cells in a syngeneic mouse model and analysis of hypoxia effect", Oncology Reports 28, 3: 1057 - 1062.
8. Pinho, S.L.C.; Faneca, H.; Geraldes, C.F.G.C.; Rocha, J.; Carlos, L.D.; Delville, M.-H.. 2012. "Silica nanoparticles for bimodal MRI-optical imaging by grafting Gd 3+ and Eu 3+/Tb 3+ complexes", European Journal of Inorganic Chemistry 2012, 16: 2828 - 2837.
9. Duarte, Sónia; Carle, Georges; Faneca, Henrique; Lima, Maria C. P.; Pierrefite-Carle, Valérie. 2012. "Suicide gene therapy in cancer: Where do we stand now?", Cancer Letters 324, 2: 160 - 170.
10. L.C. Pinho, S; Faneca, Henrique; F.G.C. Geraldes, C; Delville, Marie-Hélène; D. Carlos, L; Rocha, João. 2011. "Lanthanide-DTPA grafted silica nanoparticles as bimodal-imaging contrast agents", Biomaterials 33, 3: 925 - 935.
11. Almeida, João A. S; Faneca, Henrique; Carvalho, Rui A; Marques, Eduardo F; Pais, Alberto A. C. C; Fraternali, Franca. 2011. "Dicationic Alkylammonium Bromide Gemini Surfactants. Membrane Perturbation and Skin Irritation", PLoS ONE 6, 11: e26965 - e26977.
12. Cardoso, Ana M; Faneca, Henrique; Almeida, João A; Pais, Alberto A; Marques, Eduardo F; de Lima, M. C. P; Jurado, Amália S. 2011. "Gemini surfactant dimethylene-1,2-bis(tetradecyldimethylammonium bromide)-based gene vectors: A biophysical approach to transfection efficiency", Biochimica et Biophysica Acta (BBA) - Biomembranes 1808, 1: 341 - 351.
13. Moura, M. J; Faneca, H.; Lima, M. P; Gil, M. H; Figueiredo, M. M. 2011. "In Situ Forming Chitosan Hydrogels Prepared via Ionic/Covalent Co-Cross-Linking", Biomacromolecules 12, 9: 3275 - 3284.
14. Lundberg, Dan; Faneca, Henrique; Morán, Maria D. C; Pedroso de L. M. C; Miguel, Maria D. G; Lindman, Björn. 2011. "Inclusion of a single-tail amino acid-based amphiphile in a lipoplex formulation: Effects on transfection efficiency and physicochemical properties", Molecular Membrane Biology 28, 1: 42 - 53.
15. Duarte, Sónia; Faneca, Henrique; Pedroso de L. M. C. 2011. "Non-covalent association of folate to lipoplexes: A promising strategy to improve gene delivery in the presence of serum", Journal of Controlled Release 149, 3: 264 - 272.
16. Silva-Lucca, Rosemeire A; Faneca, Henrique M; de Lima, M. C. P; De Caroli, F. P; Assis, M.L.; Sampaio, Misako U; Oliva, Maria L. V. 2010. "Interaction of proteinase inhibitors with phospholipid vesicles is modulated by pH", International Journal of Biological Macromolecules 47, 4: 551 - 557.
17. Passadouro, Marta; Metelo, Ana M; Melão, Alice S; Pedro, Joana R; Faneca, Henrique; Carvalho, Eugénia; Castro, M. M. C. 2010. "Study of the antidiabetic capacity of the VO(dmpp)2 complex", Journal of Inorganic Biochemistry 104, 9: 987 - 992.
18. Faneca, H.; Figueiredo, V.A.; Tomaz, Isabel; Gonçalves, Gisela; Avecilla, Fernando; Pedroso de L. M; Geraldes, Carlos F; Pessoa, João C; Castro, M. M. C. 2009. "Vanadium compounds as therapeutic agents: Some chemical and biochemical studies", Journal of Inorganic Biochemistry 103, 4: 601 - 608.
19. Neves, S.; Faneca, H.; Bertin, S.; Konopka, K.; Düzgünes, N.; Pierrefite-Carle, V.; Simões, S.; Pedroso de L. M. C. 2008. "Transferrin lipoplex-mediated suicide gene therapy of oral squamous cell carcinoma in an immunocompetent murine model and mechanisms involved in the antitumoral response", Cancer Gene Therapy 16, 1: 91 - 101.
20. Trabulo, Sara; Mano, Miguel; Faneca, Henrique; Cardoso, Ana L; Duarte, Sónia; Henriques, Ana; Paiva, Artur; Gomes, Paula; Simões, Sérgio; de Lima, M. C. P. 2008. " S4 13 -PV cell penetrating peptide and cationic liposomes act synergistically to mediate intracellular delivery of plasmid DNA ", The Journal of Gene Medicine 10, 11: 1210 - 1222.
21. Faneca, H.; Faustino, A.; Pedroso de L. M. 2008. "Synergistic antitumoral effect of vinblastine and HSV-Tk/GCV gene therapy mediated by albumin-associated cationic liposomes", Journal of Controlled Release 126, 2: 175 - 184.
22. Faneca, H.; Cabrita, A.S.; Simões, S.; Pedroso de L. M. 2007. "Evaluation of the antitumoral effect mediated by IL-12 and HSV-tk genes when delivered by a novel lipid-based system", Biochimica et Biophysica Acta (BBA) - Biomembranes 1768, 5: 1093 - 1102.
23. Simões, Sérgio; Filipe, Ana; Faneca, Henrique; Mano, Miguel; Penacho, Nuno; Düzgünes, Nejat; Pedroso de L. M. 2005. "Cationic liposomes for gene delivery", Expert Opinion on Drug Delivery 2, 2: 237 - 254.
24. Faneca, H.; Simões, S.; Pedroso de L. M. C. 2004. "Association of albumin or protamine to lipoplexes: enhancement of transfection and resistance to serum", The Journal of Gene Medicine 6, 6: 681 - 692.
25. Faneca, H.; Simões, S.; Pedroso de L. M. C. 2002. "Evaluation of lipid-based reagents to mediate intracellular gene delivery", Biochimica et Biophysica Acta (BBA) - Biomembranes 1567, 1: 23 - 33.
26. Simões, S.; Fonseca, C.; Faneca, H.; Düzgünes, N.; Pedroso de L. M. 2002. "Protein-associated lipoplexes: Novel strategies to enhance gene delivery mediated by lipid-based particles", S.T.P. Pharma Sciences 12, 6: 339 - 344.
27. Pedroso de L. M. C; Simões, Sérgio; Pires, Pedro; Faneca, Henrique; Düzgünes, Nejat. 2001. "Cationic lipid–DNA complexes in gene delivery: from biophysics to biological applications", Advanced Drug Delivery Reviews 47, 2-3: 277 - 294.

Trabalhos completos/resumidos em eventos com arbitragem científica
Papers in conference proceedings with scientific refereeing
1. Passadouro, Marta; C, Nobrega; L, Almeida; Pedroso de L. M; Faneca, H. 2014. "MicroRNA-139-5p: a tool for metastasis and chemotherapeutic resistance control in Pancreatic Adenocarcinoma", Trabalho apresentado em 23rd Biennial Congress of the European Association for Cancer Research, In Eur. J. Cancer 2014, Munich.
2. Cordeiro, R.; GL, Santos; Faneca, H; JP, Mendes; AC, Serra; JFJ, Coelho. 2013. "Evaluation of the biocompatibility of cholesterol-poly[2-(dimethylamino)ethyl methacrylate] synthesized by atom transfer radical polymerization", Trabalho apresentado em IV International Symposium on Surface and Interface of Biomaterials, In Eur. Cells Mat., Rome.
3. Cordeiro, R.; GL, Santos; Faneca, H; AC, Serra; JFJ, Coelho. 2013. "Comparative biocompatibility evaluation of poly(ß-amino ester) and poly[2-(dimethylamino)ethyl methacrylate]", Trabalho apresentado em IV International Symposium on Surface and Interface of Biomaterials, In Eur. Cells Mat., Rome.
4. Farinha, Dina; Pedroso de L. M. C; Faneca, H. 2012. "A Novel Lipoplex Formulation for Targeted Cancer Gene Therapy", Trabalho apresentado em 22nd Biennial European Association of Cancer Research Congress, In Eur. J. Cancer , Barcelona.
Farinha D, Lima MP, Faneca H. A Novel Lipoplex Formulation for Targeted Cancer Gene Therapy. Eur. J. Cancer 2012;48:S248-248. .

5. F, Lebre; G, Borchard; Faneca, H; Pedroso de L. M; O, Borges. 2011. "Development of chitosan nanoparticle-DNA complexes for nasal immunization against Hepatitis B", Trabalho apresentado em AAPS National Biotechnology Conference, In Eur. J. Phar. Sci. , San Diego.
Lebre F, Borchard G, Faneca H, Pedroso de Lima MC, Borges O. Development of chitosan nanoparticle-DNA complexes for nasal immunization against Hepatitis B. Eur. J. Phar. Sci. 2011;44:139-140. .

6. MJ, Moura; Faneca, H; Pedroso de L. M; MH, Gil; Figueiredo, M. M. 2011. "The potential of a thermosensitive chitosan hydrogel cross-linked in situ with different loads of genipin", Trabalho apresentado em ICTE 2011 - II INTERNATIONAL CONFERENCE ON TISSUE ENGINEERING, In IST PRESS, Lisboa.
7. Duarte, Sónia; Faneca, H; Pedroso de L. M. C. 2010. "Development of folate-lipid-based systems for tumour-targeted gene delivery", Trabalho apresentado em 21st Meeting of the European Association for Cancer Research, In EJC SUP, Oslo.
Duarte S, Faneca H, Pedroso de Lima MC. Development of folate-lipid-based systems for tumour-targeted gene delivery. EJC SUP. 2010;8:72-72.

8. Passadouro, Marta; E, Carvalho; A, Metelo; Faneca, H; Pedroso de L. M; M, Castro. 2009. "The VO(dmpp)(2), a promising insulin mimetic vanadium compound", Trabalho apresentado em 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, In DIABETOLOGIA, Vienna.
Passadouro M, Carvalho E, Metelo AM, Faneca H, Lima MC, Castro M. The VO(dmpp)(2), a promising insulin mimetic vanadium compound. Diabet. 2009;52: S205-206. .

9. S, Trabulo; M, Mano; Faneca, H; AL, Cardoso; Duarte, Sónia; P, Gomes; S, Simões; Pedroso de L. M. 2008. "Association of S4 (13)-PV cell penetrating peptide with cationic liposomes: A synergistic effect on the intracellular delivery of plasmid DNA", Trabalho apresentado em 30th European Peptide Symposium – Cell Penetrating Peptides Satellite Symposium, In J. Pept. Sci. , Helsinki.
Trabulo S, Mano M, Faneca H, Cardoso AL, Duarte S, Gomes P, Simões S, Pedroso de Lima MC. Association of S4 (13)-PV cell penetrating peptide with cationic liposomes: A synergistic effect on the intracellular delivery of plasmid DNA. J. Pept. Sci. 2008;14:135-135.

10. Duarte, Sónia; Faneca, H; Trabulo, S.; AL, Cardoso; Pedroso de L. M. 2008. "Folate-associated cationic liposomes as a promising system for tumor-targeted gene delivery", Trabalho apresentado em European Society of Gene and Cell Therapy Meeting, In Hum. Gene. Ther , Bruges.
Duarte S, Faneca H, Trabulo S, Cardoso A, Lima MC. Folate-associated cationic liposomes as a promising system for tumor-targeted gene delivery. Hum. Gene. Ther 2008;19:1153-1153. .

11. A, Figueiredo; Faneca, H; G, Brotas; I, Tomaz; I, Correia; JC, Pessoa; F.G.C. Geraldes, C; Pedroso de L. M; M, Castro. 2006. "Evaluation of toxicity and insulin mimetic properties of vanadium compounds", Trabalho apresentado em V Symposium of Vanadium, In Am. Chem. Soc. , California.
Figueiredo A, Faneca H, Brotas G, Tomaz I, Correia I, Pessoa JC, Geraldes CFGC, Lima MCP, Castro MMCA. Evaluation of toxicity and insulin mimetic properties of vanadium compounds. Am. Chem. Soc. 2006;232:818-818.

12. Faneca, H; Cabrita, A.S.; Simões, S.; Pedroso de L. M. C. 2006. "Antitumoral activity mediated by a lipid-based gene delivery system containing therapeutic genes", Trabalho apresentado em American Society of Gene Therapy 2006 Annual Meeting, In Mol. Ther. , Baltimore.
Faneca H, Cabrita A, Simões S, Pedroso de Lima MC. Antitumoral activity mediated by a lipid-based gene delivery system containing therapeutic genes. Mol. Ther. 2006;13:S245-245. .

13. F, Avecilla; L, Palacio; A, Figueiredo; Faneca, H; JC, Pessoa; C, Geraldes; Pedroso de L. M; M, Castro. 2006. "Study of the interaction in aqueous solution of vanadate with MHCPE, a heterocyclic pyrimidinone derivative ligand, by 51V NMR spectroscopy", Trabalho apresentado em V Symposium of Vanadium, In Am. Chem. Soc. , California.
Avecilla F, Palacio L, Figueiredo A, Faneca H, Pessoa JC, Geraldes CFGC, Lima MCP, Castro MMCA. Study of the interaction in aqueous solution of vanadate with MHCPE, a heterocyclic pyrimidinone derivative ligand, by 51V NMR spectroscopy. Am. Chem. Soc. 2006;232:376-376. .

14. P, Pires; Faneca, H; Simões, S.; R, Gaspar; N, Düzgünes; Pedroso de L. M. 1996. "Interaction of cationic liposomes with cells: Insights into the mechanisms of intracellular gene transfer", Trabalho apresentado em Sixth International Congress on Cell Biology, In Mol. Biol. Cell, San Francisco.
Pires P, Faneca H, Simões S, Gaspar R, Düzgünes N, Pedroso de Lima MC. Interaction of cationic liposomes with cells: insights into the mechanisms of intracellular gene transfer. Mol. Biol. Cell 1996;7:615.









Indicadores de produção (Production indicators)

Total
Produção científica
Scientific production
45

Livros e capítulos
Books and book chapters
4
Capítulos de livros publicados
Published book chapters
4
Artigos científicos em revistas
Papers in periodics
27
Com arbitragem científica
With scientific refereeing
27
Trabalhos em eventos
Papers in conference proceedings
14
Com arbitragem científica
With scientific refereeing
14


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