Curriculum Vitae

Amélia Maria Lopes Dias da Silva

Data da última atualização »Last update : 23/11/2018


Amélia Maria Lopes Dias da Silva. É Professor Auxiliar na Universidade de Trás-os-Montes e Alto Douro. Publicou 76 artigos em revistas especializadas, possui 17 capítulos de livros publicados. Actua na área de Ciências da Saúde Nas suas actividades profissionais interagiu com 297 colaboradores em co-autorias de trabalhos científicos.


Endereço de acesso a este CV:

http://www.degois.pt/visualizador/curriculum.jsp?key=1969129387457861


Dados pessoais (Personal data)
Nome completo
Full name
Amélia Maria Lopes Dias da Silva
Nome em citações bibliográficas
Quoting name
Silva, Amélia Maria Lopes Dias da
Categoria profissional
Position
Professor Auxiliar
Domínio científico de atuação
Scientific domain
Ciências Médicas-Ciências da Saúde.
Endereço profissional
Professional address
Universidade de Trás-os-Montes e Alto Douro
Escola de Ciências da Vida e do Ambiente
Departamento de Biologia e Ambiente
Departamento de Biologia
Vila Real
5001-801 Vila Real
Portugal
Apartado: 1013
Telefone: (+351)259350106Extensão: 2106
Correio electrónico: amsilva@utad.pt
Sexo
Gender
Feminino»Female




Graus Académicos (Academic Degrees)
2003 Doutoramento
Phd
Bioquímica (especialidade Biofísica Celular).
Universidade de Coimbra, Portugal.

1992-1995 Mestrado
Master degree
Biologia Celular (2 anos » years) .
Universidade de Coimbra, Portugal.

1987-1992 Licenciatura
Licentiate degree
Bioquímica (5 anos » years) .
Universidade de Coimbra, Portugal.





Vínculos profissionais (Professional Positions)
Universidade de Trás-os-Montes e Alto Douro
Mar/2003-Actual Professor Auxiliar





Produção científica, técnica e artística/cultural (Scientific, technical and artistical/cultural production)
Capítulos de livros publicados
Published book chapters
1. Zakharova, Lucia Y; Pashirova, Tatiana N; Fernandes, Ana R; Doktorovova, Slavomira; Martins-Gomes, Carlos; SILVA, Amélia M; Souto, Eliana B. 2018. Self-assembled quaternary ammonium surfactants for pharmaceuticals and biotechnology.  In Organic Materials as Smart Nanocarriers for Drug Delivery, ed. Alexandru Mihai Grumezescu , 601 - 618. ISBN: 9780128136638. -: Elsevier.
2. Martins-Gomes, Carlos; SILVA, Amélia M. 2018. Western Blot Methodologies for Analysis of In Vitro Protein Expression Induced by Teratogenic Agents.  In Teratogenicity Testing, ed. Luís Félix, 191 - 203. ISBN: 978-1-4939-7882-3. New York, NY: Springer New York.
3. Teixeira, M.C.; Martins-Gomes, C.; Singh, K.K.; Veiga, F.J.; Silva, A.M.; Souto, E.B.. 2018. Targeting of Lipid/Polymeric (Hybrid) Nanoparticles to the Brain for the Treatment of Degenerative Diseases.  In Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors, ed. Prashant Kesharwani and Umesh Gupta, 147 - 168. ISBN: 9780128122181. -: Elsevier.
4. Fernandes, Ana R; Martins-Gomes, Carlos; Santini, Antonello; SILVA, Amélia M; Souto, Eliana B. 2018. Psoriasis vulgaris—Pathophysiology of the disease and its classical treatment versus new drug delivery systems.  In Design of Nanostructures for Versatile Therapeutic Applications, ed. Alexandru Mihai Grumezescu , 379 - 406. ISBN: 9780128136676. -: Elsevier.
5. Fernandes, Ana R; Dias-Ferreira, João; Ferreira-da-Silva, Classius; Severino, Patrícia; Martins-Gomes, Carlos; SILVA, Amélia M; Souto, Eliana B. 2018. Drug nanocrystals: present, past and future.  In Applications of Nanocomposite Materials in Drug Delivery, ed. Dr Inamuddin, Abdullah M. Asiri, Ali Mohammad, 239 - 253. ISBN: 9780128137413. -: Elsevier.
6. Zielinska, A.; Pereira, I.; Antunes, S.; Veiga, F.J.; Santos, A.C.; Nowak, I.; Silva, A.M.; Souto, E.B.. 2018. Mesoporous silica nanoparticles as drug delivery systems against melanoma.  In Design of Nanostructures for Theranostics Applications, ed. Alexandru Mihai Grumezescu, 437 - 466. ISBN: 9780128136690. -: Elsevier.
7. Souto, Eliana B; Fernandes, A. R; Ferreira, J. D; da Silva, C. F; Severino, Patrícia; Martins-Gomes, Carlos; SILVA, Amélia M. 2018. Multifunctional Nanocomposites for Biotherapeutic Applications.  In Multifunctional Nanocarriers for Contemporary Healthcare Applications, ed. Md. Abul BarkatHarshita A.B.Sarwar BegFarhan J. Ahmad, 328 - 356. ISBN: 9781522547815. -: IGI Global.
8. Teixeira, M.C.; Sanchez-Lopez, E.; Espina, M.; Calpena, A.C.; Silva, Amelia M; Veiga, F.J.; Garcia, M.L.; Souto, Eliana B. 2018. Advances in antibiotic nanotherapy.  In Emerging Nanotechnologies in Immunology, ed. R. Shegokar, E.B.Souto, William Andrew, 233 - 259. ISBN: 9780323400169. -: Elsevier.
9. SILVA, Amélia M; Siopa, João R; Martins-Gomes, Carlos; Teixeira, Maria C; Santos, Dario J; Dos Anjos P. M; Andreani, Tatiana. 2018. New strategies for the treatment of autoimmune diseases using nanotechnologies.  In Emerging Nanotechnologies in Immunology, ed. R. Shegokar, E.B.Souto, William Andrew, 135 - 163. ISBN: 9780323400169. -: Elsevier.
10. Leal, Fernanda; Taghouti, Meriem; Nunes, Fernando; Silva, Amélia M; Coelho, Ana C; Matos, Manuela. 2017. Thymus Plants: A Review?Micropropagation, Molecular and Antifungal Activity.  In Active Ingredients from Aromatic and Medicinal Plants, ed. Hany A. El-Shemy, 107 - 126. ISBN: 978-953-51-2975-2. 1: InTech.
11. Sampaio, A.C.; Aires, A.; Souto, E.B.; Silva, A.M.. 2017. Essential Oils, Polyphenols and Glycosides: Secondary Plant Metabolites Against Microbes.  In Frontiers in Clinical Drug Research-Anti Infectives, ed. Atta-ur-Rahman , 136 - 186. ISBN: 9781681083698. -: BENTHAM SCIENCE PUBLISHERS.
12. Andreani, Tatiana; Severino, Patrícia; de Hollanda, L. M; Vazzana, Monica; Souto, Selma B; Santini, Antonello; Silva, Amélia M; Souto, Eliana B. 2017. Cancer therapies: applications, nanomedicines and nanotoxicology.  In Nanostructures for Cancer Therapy, 241 - 260. ISBN: 9780323461443. Elsevier: Elsevier.
13. Severino, Patrícia; Fangueiro, Joana F; Chaud, Marco V; Cordeiro, Juliana; Silva, Amelia M; Souto, Eliana B. 2016. Advances in nanobiomaterials for topical administrations: new galenic and cosmetic formulations.  In Nanobiomaterials in Galenic Formulations and Cosmetics, 1 - 23. ISBN: 9780323428682. Elsevier: Elsevier.
14. Fangueiro, Joana F; Souto, Eliana B; Silva, Amélia M. 2016. Encapsulation of nutraceuticals in novel delivery systems.  In Nutraceuticals, 305 - 342. ISBN: 9780128043059. Elsevier: Elsevier.
15. Severino, Patrícia; de Hollanda, L. M; Santini, Antonello; Reis, Lucinda V; Souto, Selma B; Souto, Eliana B; Silva, Amélia M. 2016. Advances in nanobiomaterials for oncology nanomedicine.  In Nanobiomaterials in Cancer Therapy, 91 - 115. ISBN: 9780323428637. Elsevier: Elsevier.
16. Andreani, Tatiana; Souza, Ana L. R; SILVA, Amélia M; Souto, Eliana B. 2012. Sol–Gel Carrier System: A Novel Controlled Drug Delivery.  In Patenting Nanomedicines, ed. Eliana B. Souto, 151 - 166. ISBN: 978-3-642-29264-4. Berlin, Heidelberg: Springer Berlin Heidelberg.
17. SANTOS, Rosa M; Barbosa, Rui M; Silva, Amélia M; Antunes, Célia M; Rosario, Luis M. 1994. [Ca2+]i-sensitive conductance in the regulation of pancreatic b-cell bursting.  In Frontiers of Insulin Secretion and Pancreatic b-cell Research , ed. P. R. Flatt, & Lenzen, S.,, 181 - 186. . U.K.: Smith-Gordon.

Artigos em revistas com arbitragem científica
Papers in periodics with scientific refereeing
1. Ferreira, Sandrine S; SILVA, Amélia M; Nunes, Fernando M. 2018. "Citrus reticulata Blanco peels as a source of antioxidant and anti-proliferative phenolic compounds", Industrial Crops and Products 111, 2018: 141 - 148.
2. Silva-Abreu, Marcelle; Calpena, Ana C; Espina, Marta; Silva, Amelia M; Gimeno, Alvaro; Egea, María A; García, María L. 2018. "Optimization, Biopharmaceutical Profile and Therapeutic Efficacy of Pioglitazone-loaded PLGA-PEG Nanospheres as a Novel Strategy for Ocular Inflammatory Disorders", Pharmaceutical Research 35, 1: 1 - 14.
3. Sánchez-López, Elena; Egea, Maria A; Davis, Benjamin M; Guo, Li; Espina, Marta; Silva, Amelia M; Calpena, Ana C; Souto, Eliana M. B; Ravindran, Nivedita; Ettcheto, Miren; Camins, Antonio; García, Maria L; Cordeiro, Maria F. 2018. "Memantine-Loaded PEGylated Biodegradable Nanoparticles for the Treatment of Glaucoma", Small 14, 2: 1701808 - 1701808.
4. Martins-Gomes, Carlos; Taghouti, Meriem; Schäfer, Judith; Bunzel, Mirko; SILVA, Amélia M; Nunes, Fernando M. 2018. "Chemical characterization and bioactive properties of decoctions and hydroethanolic extracts of Thymus carnosus Boiss.", Journal of Functional Foods 43, 2018: 154 - 164.
5. Sánchez-López, Elena; Ettcheto, Miren; Egea, Maria A; Espina, Marta; Cano, Amanda; Calpena, Ana C; Camins, Antoni; Carmona, Nuria; SILVA, Amélia M; Souto, Eliana B; García, Maria L. 2018. "Memantine loaded PLGA PEGylated nanoparticles for Alzheimer’s disease: in vitro and in vivo characterization", Journal of Nanobiotechnology 16, 1: 1 - 16.
6. Carbone, C.; Martins-Gomes, C.; Pepe, V.; Silva, A.M.; Musumeci, T.; Puglisi, G.; Furneri, P.M.; Souto, E.B.. 2018. "Repurposing itraconazole to the benefit of skin cancer treatment: A combined azole-DDAB nanoencapsulation strategy", Colloids and Surfaces B: Biointerfaces 167, 2018: 337 - 344.
7. Sario, Sara; SILVA, Amélia M; Gaivão, Isabel. 2018. "Titanium dioxide nanoparticles: Toxicity and genotoxicity in Drosophila melanogaster (SMART eye-spot test and comet assay in neuroblasts)", Mutation Research/Genetic Toxicology and Environmental Mutagenesis 831, 2018: 19 - 23.
8. Taghouti, Meriem; Martins-Gomes, Carlos; Schäfer, Judith; Félix, Luis M; Santos, João A; Bunzel, Mirko; Nunes, Fernando M; SILVA, Amélia M. 2018. " Thymus pulegioides L. as a rich source of antioxidant, anti-proliferative and neuroprotective phenolic compounds ", Food & Function 9, 7: 3617 - 3629.
9. Carbone, C.; Martins-Gomes, C.; Caddeo, C.; Silva, A.M.; Musumeci, T.; Pignatello, R.; Puglisi, G.; Souto, E.B.. 2018. "Mediterranean essential oils as precious matrix components and active ingredients of lipid nanoparticles", International Journal of Pharmaceutics 548, 1: 217 - 226.
10. Pereira, Irina; Zielinska, Aleksandra; Ferreira, Nuno R; SILVA, Amélia M; Souto, Eliana B. 2018. "Optimization of linalool-loaded solid lipid nanoparticles using experimental factorial design and long-term stability studies with a new centrifugal sedimentation method", International Journal of Pharmaceutics 549, 1-2: 261 - 270.
11. Pereira, Irina; Severino, Patrícia; Santos, Ana C; SILVA, Amélia M; Souto, Eliana B. 2018. "Linalool bioactive properties and potential applicability in drug delivery systems", Colloids and Surfaces B: Biointerfaces 171, 2018: 566 - 578.
12. Zielinska, Aleksandra; Martins-Gomes, Carlos; Ferreira, Nuno R; SILVA, Amélia M; Nowak, Izabela; Souto, Eliana B. 2018. "Anti-inflammatory and anti-cancer activity of citral: Optimization of citral-loaded solid lipid nanoparticles (SLN) using experimental factorial design and LUMiSizer®", International Journal of Pharmaceutics 553, 1-2: 428 - 440.
13. Sampaio, A.C.; Mendes, R.J.; Castro, P.G.; Silva, A.M.. 2017. "Solid lipid nanoparticles affect microbial colonization and enzymatic activity throughout the decomposition of alder leaves in freshwater microcosms", Ecotoxicology and Environmental Safety 135, -: 375 - 380.
14. Kiilll, Charlene P; Barud, Hernane S; Santagneli, Sílvia H; Ribeiro, Sidney J. L; SILVA, Amélia M; Tercjak, Agnieszka; Gutierrez, Junkal; Pironi, Andressa M; Gremião, Maria P. D. 2017. "Synthesis and factorial design applied to a novel chitosan/sodium polyphosphate nanoparticles via ionotropic gelation as an RGD delivery system", Carbohydrate Polymers 157, -: 1695 - 1702.
15. Teixeira, M.C.; Severino, P.; Andreani, T.; Boonme, P.; Santini, A.; Silva, A.M.; Souto, E.B.. 2017. "d -alpha-tocopherol nanoemulsions: Size properties, rheological behavior, surface tension, osmolarity and cytotoxicity", Saudi Pharmaceutical Journal 25, 2: 231 - 235.
16. Friães, Sofia; SILVA, Amélia M; Boto, Renato E; Ferreira, Diana; Fernandes, José R; Souto, Eliana B; Almeida, Paulo; Ferreira, Luis F. V; Reis, Lucinda V. 2017. "Synthesis, spectroscopic characterization and biological evaluation of unsymmetrical aminosquarylium cyanine dyes", Bioorganic & Medicinal Chemistry 25, 14: 3803 - 3814.
17. Queiroz, Marcelo; Oppolzer, David; Gouvinhas, Irene; SILVA, Amélia M; Barros, Ana I; Domínguez-Perles, Raúl. 2017. "New grape stems' isolated phenolic compounds modulate reactive oxygen species, glutathione, and lipid peroxidation in vitro : Combined formulations with vitamins C and E", Fitoterapia 120, 2017: 146 - 157.
18. Sousa, C.; Pereira, I.; Santos, A.C.; Carbone, C.; Kova¿?evic, A.B.; Silva, A.M.; Souto, E.B.. 2017. "Targeting dendritic cells for the treatment of autoimmune disorders", Colloids and Surfaces B: Biointerfaces 158, 2017: 237 - 248.
19. Fernandes, A.R.; Ferreira, N.R.; Fangueiro, J.F.; Santos, A.C.; Veiga, F.J.; Cabral, C.; Silva, A.M.; Souto, E.B.. 2017. "Ibuprofen nanocrystals developed by 22 factorial design experiment: A new approach for poorly water-soluble drugs", Saudi Pharmaceutical Journal 25, 8: 1117 - 1124.
20. Doktorovova, Slavomira; Souto, Eliana B; SILVA, Amélia M. 2017. " Hansen solubility parameters (HSP) for prescreening formulation of solid lipid nanoparticles (SLN): in vitro testing of curcumin-loaded SLN in MCF-7 and BT-474 cell lines ", Pharmaceutical Development and Technology 23, 1: 96 - 105.
21. Cañadas, Cristina; Alvarado, Helen; Calpena, Ana C; SILVA, Amélia M; Souto, Eliana B; García, Maria L; Abrego, Guadalupe. 2016. "In vitro, ex vivo and in vivo characterization of PLGA nanoparticles loading pranoprofen for ocular administration", International Journal of Pharmaceutics 511, 2: 719 - 727.
22. Domínguez-Perles, Raúl; Guedes, Ana; Queiroz, Marcelo; SILVA, Amélia M; Barros, Ana I. 2016. "Oxidative stress prevention and anti-apoptosis activity of grape (Vitis vinifera L.) stems in human keratinocytes", Food Research International 87, -: 92 - 102.
23. Boonme, Prapaporn; Kaewbanjong, Jarika; Amnuaikit, Thanaporn; Andreani, Tatiana; Silva, Amélia; Souto, Eliana. 2016. "Microemulsion and Microemulsion-Based Gels for Topical Antifungal Therapy with Phytochemicals", Current Pharmaceutical Design 22, 27: 4257 - 4263.
24. Fujimura, Andressa T; Martinez, Renata M; Pinho-Ribeiro, Felipe A; Lopes Dias S. A. M; Baracat, Marcela M; Georgetti, Sandra R; Verri, Waldiceu A; Chorilli, Marlus; Casagrande, Rubia. 2016. "Resveratrol-Loaded Liquid-Crystalline System Inhibits UVB-Induced Skin Inflammation and Oxidative Stress in Mice", Journal of Natural Products 79, 5: 1329 - 1338.
25. Sánchez-López, E.; Egea, M.A.; Cano, A.; Espina, M.; Calpena, A.C.; Ettcheto, M.; Camins, A.; Souto, E.B.; Silva, A.M.; García, M.L.. 2016. "PEGylated PLGA nanospheres optimized by design of experiments for ocular administration of dexibuprofen—in vitro, ex vivo and in vivo characterization", Colloids and Surfaces B: Biointerfaces 145, -: 241 - 250.
26. Santos, Stefanie; SILVA, Amélia M; Matos, Manuela; Monteiro, Sandra M; ¿?lvaro, Ana R. 2016. "Copper induced apoptosis in Caco-2 and Hep-G2 cells: Expression of caspases 3, 8 and 9, AIF and p53", Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 185186, -: 138 - 146.
27. Fangueiro, Joana F; Calpena, Ana C; Clares, Beatriz; Andreani, Tatiana; Egea, Maria A; Veiga, Francisco J; Garcia, Maria L; SILVA, Amélia M; Souto, Eliana B. 2016. "Biopharmaceutical evaluation of epigallocatechin gallate-loaded cationic lipid nanoparticles (EGCG-LNs): In vivo, in vitro and ex vivo studies", International Journal of Pharmaceutics 502, 1-2: 161 - 169.
28. Fangueiro, Joana; Veiga, Francisco; Silva, Amelia; Souto, Eliana. 2016. "Ocular Drug Delivery - New Strategies for Targeting Anterior and Posterior Segments of the Eye", Current Pharmaceutical Design 22, 9: 1135 - 1146.
29. Severino, Patrícia; Szymanski, Marcelo; Favaro, Marianna; Azzoni, Adriano R; Chaud, Marco V; Santana, Maria H. A; SILVA, Amélia M; Souto, Eliana B. 2015. "Development and characterization of a cationic lipid nanocarrier as non-viral vector for gene therapy", European Journal of Pharmaceutical Sciences 66, -: 78 - 82.
30. Soares, Jorge P; Silva, Amélia M; Fonseca, Sandra; Oliveira, Maria M; Peixoto, Francisco; Gaivão, Isabel; Mota, Maria P. 2015. "How can age and lifestyle variables affect DNA damage, repair capacity and endogenous biomarkers of oxidative stress?", Experimental Gerontology 62, -: 45 - 52.
31. Andreani, Tatiana; SILVA, Amélia M; Souto, Eliana B. 2015. "Silica based-matrices: State of the art and new perspectives for therapeutic drug delivery", Biotechnology and Applied Biochemistry n, -: n/a - n/a.
32. Fangueiro, Joana F; SILVA, Amélia M; Garcia, Maria L; Souto, Eliana B. 2015. "Current nanotechnology approaches for the treatment and management of diabetic retinopathy", European Journal of Pharmaceutics and Biopharmaceutics, -: na - na.
33. Vazzana, M.; Andreani, T.; Fangueiro, J.; Faggio, C.; Silva, C.; Santini, A.; Garcia, M.L.; Silva, A.M.; Souto, E.B.. 2015. "Tramadol hydrochloride: Pharmacokinetics, pharmacodynamics, adverse side effects, co-administration of drugs and new drug delivery systems", Biomedicine & Pharmacotherapy 70, 2015: 234 - 238.
34. Andreani, Tatiana; Miziara, Leonardo; Lorenzón, Esteban N; de Souza, A. L. R; Kiill, Charlene P; Fangueiro, Joana F; Garcia, Maria L; Gremião, Palmira D; SILVA, Amélia M; Souto, Eliana B. 2015. "Effect of mucoadhesive polymers on the in vitro performance of insulin-loaded silica nanoparticles: Interactions with mucin and biomembrane models", European Journal of Pharmaceutics and Biopharmaceutics 93, -: 118 - 126.
35. Andreani, Tatiana; Kiill, Charlene P; de Souza, A. L. R; Fangueiro, Joana F; Doktorovová, Slavomira; Garcia, Maria L; Gramião, Maria P. D; SILVA, Amélia M; Souto, Eliana B. 2015. "Effect of cryoprotectants on the reconstitution of silica nanoparticles produced by sol–gel technology", Journal of Thermal Analysis and Calorimetry 120, 1: 1001 - 1007.
36. Andreani, Tatiana; Fangueiro, Joana; Jose, Sajan; Santini, Antonello; Silva, Amelia; Souto, Eliana. 2015. "Hydrophilic Polymers for Modified-Release Nanoparticles: A Review of Mathematical Modelling for Pharmacokinetic Analysis", Current Pharmaceutical Design 21, 22: 3090 - 3096.
37. Soares, Jorge P; SILVA, Amélia M; Oliveira, Maria M; Peixoto, Francisco; Gaivão, Isabel; Mota, Maria P. 2015. "Effects of combined physical exercise training on DNA damage and repair capacity: role of oxidative stress changes", AGE 37, 3: 1 - 12.
38. Ribeiro, Miguel; Nunes, Fernando M; Guedes, Sofia; Domingues, Pedro; SILVA, Amélia M; Carrillo, Jose M; Rodriguez-Quijano, Marta; Branlard, Gérard; Igrejas, Gilberto. 2015. "Efficient chemo-enzymatic gluten detoxification: reducing toxic epitopes for celiac patients improving functional properties", Scientific Reports 5, -: 18041 - 18041.
39. Soares, Jorge P; Silva, Ana I; SILVA, Amélia M; Almeida, Vanessa; Teixeira, João P; Matos, Manuela; Gaivão, Isabel; Mota, Maria P. 2015. " Effects of physical exercise training in DNA damage and repair activity in humans with different genetic polymorphisms of hOGG1 (Ser326Cys) ", Cell Biochemistry and Function 33, 8: 519 - 524.
40. Macedo, Ana S; Quelhas, Sara; SILVA, Amélia M; Souto, Eliana B. 2014. " Nanoemulsions for delivery of flavonoids: formulation and in vitro release of rutin as model drug ", Pharmaceutical Development and Technology 19, 6: 677 - 680.
41. Doktorovova, Slavomira; Shegokar, Ranjita; Fernandes, Lisete; Martins-Lopes, Paula; SILVA, Amélia M; Müller, Rainer H; Souto, Eliana B. 2014. "Trehalose is not a universal solution for solid lipid nanoparticles freeze-drying", Pharmaceutical Development and Technology 19, 8: 922 - 929.
42. Doktorovova, Slavomira; SILVA, Amélia M; Gaivão, Isabel; Souto, Eliana B; Teixeira, João P; Martins-Lopes, Paula. 2014. "Comet assay reveals no genotoxicity risk of cationic solid lipid nanoparticles", Journal of Applied Toxicology 34, 4: 395 - 403.
43. Monteiro-Cardoso, Vera F; SILVA, Amélia M; Oliveira, Maria M; Peixoto, Francisco; Videira, Romeu A. 2014. "Membrane lipid profile alterations are associated with the metabolic adaptation of the Caco-2 cells to aglycemic nutritional condition", Journal of Bioenergetics and Biomembranes 46, 1: 45 - 57.
44. Fangueiro, Joana F; Andreani, Tatiana; Egea, Maria A; Garcia, Maria L; Souto, Selma B; SILVA, Amélia M; Souto, Eliana B. 2014. "Design of cationic lipid nanoparticles for ocular delivery: Development, characterization and cytotoxicity", International Journal of Pharmaceutics 461, 1-2: 64 - 73.
45. Souza, Ana L. R.; Andreani, Tatiana; de Oliveira, R. N; Kiill, Charlene P; Santos, Fernanda K.; Allegretti, Silmara M; Chaud, Marco V; Souto, Eliana B; SILVA, Amélia M; Gremião, Maria P. D. 2014. "In vitro evaluation of permeation, toxicity and effect of praziquantel-loaded solid lipid nanoparticles against Schistosoma mansoni as a strategy to improve efficacy of the schistosomiasis treatment", International Journal of Pharmaceutics 463, 1: 31 - 37.
46. Doktorovova, Slavomira; Souto, Eliana B; SILVA, Amélia M. 2014. "Nanotoxicology applied to solid lipid nanoparticles and nanostructured lipid carriers – A systematic review of in vitro data", European Journal of Pharmaceutics and Biopharmaceutics 87, 1: 1 - 18.
47. Sousa, Cristina P; Azevedo, Jorge T; SILVA, Amélia M; Viegas, Carlos A; Reis, Rui L; Gomes, Manuela E; Dias, Isabel R. 2014. "Serum total and bone alkaline phosphatase levels and their correlation with serum minerals over the lifespan of sheep", Acta Veterinaria Hungarica 62, 2: 205 - 214.
48. Doktorovová, Slavomira; Santos, Dario L; Costa, Inês; Andreani, Tatiana; Souto, Eliana B; SILVA, Amélia M. 2014. "Cationic solid lipid nanoparticles interfere with the activity of antioxidant enzymes in hepatocellular carcinoma cells", International Journal of Pharmaceutics 471, 1-2: 18 - 27.
49. Severino, Patrícia; Andreani, Tatiana; Jäger, Alessandro; Chaud, Marco V; Santana, Maria H. A; SILVA, Amélia M; Souto, Eliana B. 2014. "Solid lipid nanoparticles for hydrophilic biotech drugs: Optimization and cell viability studies (Caco-2 & HEPG-2 cell lines)", European Journal of Medicinal Chemistry 81, -: 28 - 34.
50. Andreani, Tatiana; Souza, Ana L. R.; Kiill, Charlene P; Lorenzón, Esteban N; Fangueiro, Joana F; Calpena, Ana C; Chaud, Marco V; Garcia, Maria L; Gremião, Maria P. D; SILVA, Amélia M; Souto, Eliana B. 2014. "Preparation and characterization of PEG-coated silica nanoparticles for oral insulin delivery", International Journal of Pharmaceutics 473, 1-2: 627 - 635.
51. Fangueiro, Joana F; Parra, Alexander; SILVA, Amélia M; Egea, Maria A; Souto, Eliana B; Garcia, Maria L; Calpena, Ana C. 2014. "Validation of a high performance liquid chromatography method for the stabilization of epigallocatechin gallate", International Journal of Pharmaceutics 475, 1-2: 181 - 190.
52. Andreani, Tatiana; Kiill, Charlene P; Souza, Ana L. R.; Fangueiro, Joana F; Fernandes, Lisete; Doktorovová, Slavomira; Santos, Dario L; Garcia, Maria L; Gremião, Maria P. D; Souto, Eliana B; SILVA, Amélia M. 2014. "Surface engineering of silica nanoparticles for oral insulin delivery: Characterization and cell toxicity studies", Colloids and Surfaces B: Biointerfaces 123, -: 916 - 923.
53. Fangueiro, Joana F; Andreani, Tatiana; Fernandes, Lisete; Garcia, Maria L; Egea, Maria A; SILVA, Amélia M; Souto, Eliana B. 2014. "Physicochemical characterization of epigallocatechin gallate lipid nanoparticles (EGCG-LNs) for ocular instillation", Colloids and Surfaces B: Biointerfaces 123, -: 452 - 460.
54. Silva, Amélia M; Miranda, Andreia; Fernandes, Elisabete; Santos, Susana; Fraga, Irene; Santos, Dario L; Dias, Albino A; Bezerra, Rui M. 2013. "Endopolysaccharides from Ganoderma resinaceum, Phlebia rufa, and Trametes versicolor Affect Differently the Proliferation Rate of HepG2 Cells", Applied Biochemistry and Biotechnology 169, 6: 1919 - 1926.
55. Santos, Isis S; Ponte, Bruno M; Boonme, Prapaporn; Silva, Amélia M; Souto, Eliana B. 2013. "Nanoencapsulation of polyphenols for protective effect against colon–rectal cancer", Biotechnology Advances 31, 5: 514 - 523.
56. Andreani, Tatiana; Sofia Macedo, A; F. Ferreira, S; M. Silva, A; Rosmaninho, Aristoteles; B. Souto, E. 2012. "Topical Targeting Therapies for Sexually Transmitted Diseases", Current Nanoscience 8, 4: 486 - 490.
57. Severino, Patrícia; Andreani, Tatiana; Macedo, Ana S; Fangueiro, Joana F; Santana, Maria H. A; Silva, Amélia M; Souto, Eliana B. 2012. "Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery", Journal of Drug Delivery 2012, 2012: 1 - 10.
58. Doktorovova, S.; Shegokar, R.; Martins-Lopes, P.; Silva, A.M.; Lopes, C.M.; Müller, R.H.; Souto, E.B.. 2012. "Modified Rose Bengal assay for surface hydrophobicity evaluation of cationic solid lipid nanoparticles (cSLN)", European Journal of Pharmaceutical Sciences 45, 5: 606 - 612.
59. Souza, Ana L. R; Andreani, Tatiana; Nunes, Fernando M; Cassimiro, Douglas L; Almeida, Adélia E; Ribeiro, Clóvis A; Sarmento, Victor H. V; Gremião, Maria P. D; Silva, Amélia M; Souto, Eliana B. 2011. "Loading of praziquantel in the crystal lattice of solid lipid nanoparticles", Journal of Thermal Analysis and Calorimetry 108, 1: 353 - 360.
60. Doktorovova, S.; Shegokar, R.; Rakovsky, E.; Gonzalez-Mira, E.; Lopes, C.M.; Silva, A.M.; Martins-Lopes, P.; Muller, R.H.; Souto, E.B.. 2011. "Cationic solid lipid nanoparticles (cSLN): Structure, stability and DNA binding capacity correlation studies", International Journal of Pharmaceutics 420, 2: 341 - 349.
61. Dias, I.R.; Viegas, C.A.; Silva, A.M.; Pereira, H.F.; Sousa, C.P.; Carvalho, P.P.; Cabrita, A.S.; Fontes, P.J.; Silva, S.R.; Azevedo, J.M.T.. 2010. "Haematological and biochemical parameters in Churra-da-Terra-Quente ewes from the northeast of Portugal", ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA  62, 2: 265 - 272.
62. Souto, Eliana B; Martins-Lopes, Paula; Lopes, Carla M; Gaivão, Isabel; Silva, Amélia M; Guedes-Pinto, Henrique. 2009. "A Note on Regulatory Concerns and Toxicity Assessment in Lipid-Based Delivery Systems (LDS)", Journal of Biomedical Nanotechnology 5, 4: 317 - 322.
63. Misler, Stanley; Zhou, Zhuan; Dickey, Adam S; Silva, Amelia M; Pressel, David M; Barnett, David W. 2009. " Electrical activity and exocytotic correlates of biphasic insulin secretion from ß-cells of canine islets of Langerhans: Contribution of tuning two modes of Ca 2+ entry-dependent exocytosis to two modes of glucose-induced electrical activity ", Channels 3, 3: 181 - 193.
64. Misler, Stanley; Silva, Amelia M; Barnett, David W; Dickey, Adam S. 2009. "Phasic and tonic modes of depolarization-exocytosis coupling in ß-cells of porcine islets of Langerhans", Channels 3, 2: 101 - 109.
65. Silva, Amelia M; Dickey, Adam S; Barnett, David W; Misler, Stanley. 2009. "Ion channels underlying stimulus-exocytosis coupling and its cell-to-cell heterogeneity in ß-cells of transplantable porcine islets of Langerhans", Channels 3, 2: 91 - 100.
66. Rosário, Luís M; BARBOSA, Rui M; ANTUNES, Célia M; BALDEIRAS, Inês E; SILVA, Amélia M; TOMÉ, Ângelo R; SANTOS, Rosa M. 2008. "Regulation by Glucose of Oscillatory Electrical Activity and 5-HT/Insulin Release from Single Mouse Pancreatic Islets in Absence of Functional KATP Channels", Endocrine Journal 55, 4: 639 - 650.
67. Silva, Amélia M; Rodrigues, Ricardo J; Tomé, Ângelo R; Cunha, Rodrigo A; Misler, Stanley; Rosário, Luís M; Santos, Rosa M. 2008. "Electrophysiological and Immunocytochemical Evidence for P2X Purinergic Receptors in Pancreatic ß Cells", Pancreas 36, 3: 279 - 283.
68. Morais, Raul; Valente, A.; Almeida, J.C.; Silva, Amélia M; Soares, Salviano; Reis, M.J.C.S.; Valentim, R.; Azevedo, Jorge. 2006. "Concept study of an implantable microsystem for electrical resistance and temperature measurements in dairy cows, suitable for estrus detection", Sensors and Actuators A: Physical 132, 1: 354 - 361.
69. Silva, A. M; Liu-Gentry, J.; Dickey, A.S.; Barnett, D.W.; Misler, S.. 2005. "alpha-Latrotoxin increases spontaneous and depolarization-evoked exocytosis from pancreatic islet beta-cells", JOURNAL OF PHYSIOLOGY-LONDON  565, 3: 783 - 799.
70. Barbosa, Rui M; Silva, Amelia M; Tome, Angelo R; Stamford, Jonathan A; Santos, Rosa M; Rosario, Luis M. 1998. "Control of pulsatile 5-HT/insulin secretion from single mouse pancreatic islets by intracellular calcium dynamics", JOURNAL OF PHYSIOLOGY-LONDON  510, 1: 135 - 143.
71. Santos, R. M; Barbosa, R.M.; C.M., Antunes.; Silva, A.M.; Salgado, A.P.; Abrunhosa, A.J.; Pereira, F.C.; Seiça, R.M.; Rosário, L.M.. 1997. "Bursting electrical activity generated in the presence of KATP channel blockers. Pharmacology, sensitivity to intracellular pH and modulation by glucose metabolism", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, 426: 33 - 45.
72. Barbosa, Rui M; Silva, Amélia M; Tome, Angelo R; Stamford, Jonathan A; Santos, Rosa M; Rosario, Luis M. 1996. "Real Time Electrochemical Detection of 5-HT/Insulin Secretion from Single Pancreatic Islets: Effect of Glucose and K+Depolarization", Biochemical and Biophysical Research Communications 228, 1: 100 - 104.
73. Salgado, A.P.; Silva, A.M.; Santos, R. M; Rosário, L.M.. 1996. "Multiphasic action of glucose and alpha-keto isocaproic acid on the intracellular pH of isolated mouse pancreatic beta-cells.", Journal of Biological Chemistry  271, 15: 8738 - 8467.
74. Silva, Amélia M; Rosario, Luis M; Santos, Rosa M. 1994. "Background Ca2+ influx mediated by a dihydropyridine- and voltage insensitive channel in pancreatic *-cells: modulation by Ni2+, diphenylamine-2-carboxylate and glucose metabolism. ", Journal of Biological Chemistry  269, 25: 17095 - 17103.
75. Rosario, Luis M; Barbosa, Rui M; Antunes, Célia M; Silva, Amélia M; Abrunhosa, Antero J; Santos, Rosa M. 1993. "Bursting electrical activity in pancreatic beta-cells: evidence that the channel underlying the burst is sensitive to Ca2+ influx through L-type Ca2+ channels", Pflugers Archiv European Journal of Physiology 424, 5-6: 439 - 447.
76. Santos, Rosa M; Barbosa, Rui M; Silva, Amélia M; Antunes, Célia M; Rosario, Luis M. 1992. "High external Ca2+ levels trigger membrane potential oscillations in mouse pancreatic ß-cells during blockade of K(ATP) channels", Biochemical and Biophysical Research Communications 187, 2: 872 - 879.








Indicadores de produção (Production indicators)

Total
Produção científica
Scientific production
93

Livros e capítulos
Books and book chapters
17
Capítulos de livros publicados
Published book chapters
17
Artigos científicos em revistas
Papers in periodics
76
Com arbitragem científica
With scientific refereeing
76


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